KT-474( —— )

Catalog No. M36599 CAS No. 2432994-31-3

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Product Name

KT-474
Note

Research use only, not for human use.
Brief Description

KT-474 (KYM-001) is a PROTAC degrader targeting interleukin-1 receptor-associated kinase 4 (IRAK4) with antitumor activity for the study of autoimmune, inflammatory, and cardiovascular disease disorders.
Description

KT-474 (KYM-001) is an orally active PROTAC IRAK4 degrader with antitumor activities. KT-474 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
In Vitro

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In Vivo

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Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

PROTACs
Research Area

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Indication

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CAS Number

2432994-31-3
Formula Weight

865.93
Molecular Formula

C44H49F2N11O6
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (115.48 mM; Ultrasonic )
SMILES

O=C1N(C=2C(=C(C#CCOC3CCN(C[C@H]4CC[C@@H](CC4)N5C=C(NC(=O)C6=C7N(N=C6)C=CC(=N7)N8[C@@]9(C[C@](C8)(OC9)[H])[H])C(C(F)F)=N5)CC3)C=CC2)N1C)C%10C(=O)NC(=O)CC%10
Chemical Name

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1. Nello Mainolfi, et al. Irak degraders and uses thereof. Patent WO2020113233A1.

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