KDM5-C49( KDM5 inhibitor C49 )

Catalog No. M12279 CAS No. 1596348-16-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

KDM5-C49
Note

Research use only, not for human use.
Brief Description

KDM5-C49 is a potent, selective KDM5 inhibitor with IC50 of 25, 30 and 59 nM for KDM5A, B and C, respectively.
Description

KDM5-C49 is a potent, selective KDM5 inhibitor with IC50 of 25, 30 and 59 nM for KDM5A, B and C, respectively; displays 25-100-fold selectivity over KDM6B, 2-30-fold selectivity over KDM4 family, but with less cell-permeablity.
In Vitro

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In Vivo

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Synonyms

KDM5 inhibitor C49
Pathway

Chromatin/Epigenetic
Target

Histone Demethylase
Recptor

Histone Demethylase
Research Area

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Indication

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CAS Number

1596348-16-1
Formula Weight

308.382
Molecular Formula

C15H24N4O3
Purity

>98% (HPLC)
Solubility

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SMILES

O=C(O)C1=CC=NC(CNCC(N(CCN(C)C)CC)=O)=C1
Chemical Name

2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinic acid

1. Johansson C, et. Nat Chem Biol. 2016 Jul;12(7):539-45. 2. Horton JR, et al. Cell Chem Biol. 2016 Jul 21;23(7):769-81.

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