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KCI807
CAS No. 6665-68-5
KCI807( KCI-807 | KCI 807 )
Catalog No. M15543 CAS No. 6665-68-5
KCI807 (KCI-807) is a lead molecule that selectively disrupts ELK1-dependent promoter activation by wild-type and variant Ars (IC50=0.53 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 100MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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Biological Information
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Product NameKCI807
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NoteResearch use only, not for human use.
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Brief DescriptionKCI807 (KCI-807) is a lead molecule that selectively disrupts ELK1-dependent promoter activation by wild-type and variant Ars (IC50=0.53 uM).
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DescriptionKCI807 (KCI-807) is a lead molecule that selectively disrupts ELK1-dependent promoter activation by wild-type and variant Ars (IC50=0.53 uM) without interfering with ELK1 activation by ERK; binds to AR (Kd=69.2 nM), blocking ELK1 binding, and selectively blocks recruitment of AR to chromatin by ELK1; primarily affects a subset of AR target growth genes selectively suppressing AR-dependent growth of PC cell lines with a better inhibitory profile than Enzalutamide; also inhibits in vivo growth of castration/enzalutamide-resistant cell line-derived and patient-derived tumor xenografts.
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In Vitro——
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In Vivo——
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SynonymsKCI-807 | KCI 807
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PathwayEndocrinology/Hormones
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TargetAndrogen Receptor (AR)
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RecptorAndrogen Receptor (AR)
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Research Area——
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Indication——
Chemical Information
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CAS Number6665-68-5
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Formula Weight254.241
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Molecular FormulaC15H10O4
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Purity>98% (HPLC)
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Solubility——
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SMILESC1=CC(=CC(=C1)O)C2=CC(=O)C3=C(C=CC=C3O2)O
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Chemical Name5-hydroxy-2-(3-hydroxyphenyl)-4H-chromen-4-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Rosati R, et al. Clin Cancer Res. 2018 Sep 5. pii: clincanres.0982.2018. doi: 10.1158/1078-0432.CCR-18-0982.
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