JNJ-64619178( —— )

Catalog No. M23934 CAS No. 2086772-26-9

JNJ-64619178 is a selective, orally active, and pseudo-irreversible inhibitor of protein arginine methyltransferase 5 (IC50: 0.14 nM).

Purity : >98% (HPLC)

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Biological Information

Product Name

JNJ-64619178
Note

Research use only, not for human use.
Brief Description

JNJ-64619178 is a selective, orally active, and pseudo-irreversible inhibitor of protein arginine methyltransferase 5 (IC50: 0.14 nM).
Description

JNJ-64619178 is a selective, orally active, and pseudo-irreversible inhibitor of protein arginine methyltransferase 5 (IC50: 0.14 nM). It has effective activity In lung cancer.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Chromatin/Epigenetic
Target

Histone Demethylase
Recptor

PRMT5
Research Area

——
Indication

——

Chemical Information

CAS Number

2086772-26-9
Formula Weight

483.36
Molecular Formula

C22H23BrN6O2
Purity

>98% (HPLC)
Solubility

DMSO: 120 mg/mL (248.26 mM; Need ultrasonic)
SMILES

Nc1c(ccn2[C@H](C[C@H](CCc3ccc(cc(c(N)n4)Br)c4c3)[C@H]3O)[C@@H]3O)c2ncn1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Tongfei Wu, et al. Abstract 4859: JNJ-64619178, a selective and pseudo-irreversible PRMT5 inhibitor with potent in vitro and in vivo activity, demonstrated in several lung cancer models.

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