JNJ-26070109( JNJ 26070109 | JNJ26070109 )

Catalog No. M16137 CAS No. 844645-08-5

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Product Name

JNJ-26070109
Note

Research use only, not for human use.
Brief Description

A novel, potent, selective orally active CCK-2 receptor antagonist with pKi of 8.49 for hCCK2.
Description

A novel, potent, selective orally active CCK-2 receptor antagonist with pKi of 8.49 for hCCK2; displays >1200-fold selectivity over hCCK1 receptor; has oral EC50 of 1.5 and 0.26 uM in conscious rat and dog chronic gastric fistula models of pentagastrin-stimulated acid secretion, respectively; inhibits gastric acid secretion and prevents omeprazole-induced acid rebound in the rats.
In Vitro

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In Vivo

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Synonyms

JNJ 26070109 | JNJ26070109
Pathway

GPCR/G Protein
Target

Cholecystokinin Receptor
Recptor

Cholecystokinin Receptor
Research Area

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Indication

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CAS Number

844645-08-5
Formula Weight

547.37
Molecular Formula

C23H17BrF2N4O3S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(N[C@@H](C1=CC=C(F)C=C1F)C)C2=CC=C(Br)C=C2NS(=O)(C3=C4N=CC=NC4=CC=C3)=O
Chemical Name

(R)-4-Bromo-N-[1-(2,4-difluorophenyl)ethyl]-2-[[(quinoxalin-5-yl)sulfonyl]amino]benzamide

1. Morton MF, et al. J Pharmacol Exp Ther. 2011 Jul;338(1):328-36. 2. Barrett TD, et al. Br J Pharmacol. 2012 Jul;166(5):1684-93.

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