JNJ-1661010( JNJ-1661010 | JNJ 1661010 | JNJ1661010 )

Catalog No. M18990 CAS No. 681136-29-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

JNJ-1661010
Note

Research use only, not for human use.
Brief Description

JNJ-1661010 is an effective and specific FAAH inhibitor (IC50: 10/ 12 nM for rat/human), shows >100-fold selectivity for FAAH-1 than FAAH-2.
Description

JNJ-1661010 is a selective, reversible inhibitor of fatty acid amide hydrolase (FAAH) (IC50 = 12 nM). JNJ-1661010 is a brain penetrant and active in vivo.
In Vitro

——
In Vivo

JNJ-1661010 (Takeda-25; i.p.; 50 mg/kg) diminishes thermal hyperalgesia in the inflammatory rat carrageenan paw model. JNJ-1661010 (i.p.; 10 mg/kg) has a T1/2 of 35 mins, a CL of 0.032 mL/min/kg, and a Cmax of 1.58 μM for rats.
Synonyms

JNJ-1661010 | JNJ 1661010 | JNJ1661010
Pathway

Others
Target

Other Targets
Recptor

FAAH (human)| FAAH (rat)
Research Area

Others-Field
Indication

——

CAS Number

681136-29-8
Formula Weight

365.45
Molecular Formula

C19H19N5OS
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (273.64 mM)
SMILES

O=C(Nc1ccccc1)N1CCN(CC1)c1nc(ns1)c1ccccc1
Chemical Name

1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-

1. Karbarz MJ, et al. Anesth Analg, 2009, 108(1), 316-329.

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