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JKE-1674
CAS No. 2421119-60-8
JKE-1674( —— )
Catalog No. M28123 CAS No. 2421119-60-8
JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4). JKE-1674 is an active metabolite of the GPX4 inhibitor ML-210.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 102 | Get Quote |
|
| 10MG | 165 | Get Quote |
|
| 25MG | 335 | Get Quote |
|
| 50MG | 537 | Get Quote |
|
| 100MG | 860 | Get Quote |
|
| 200MG | 1152 | Get Quote |
|
| 500MG | 1701 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameJKE-1674
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NoteResearch use only, not for human use.
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Brief DescriptionJKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4). JKE-1674 is an active metabolite of the GPX4 inhibitor ML-210.
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DescriptionJKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4). JKE-1674 is an active metabolite of the GPX4 inhibitor ML-210.(In Vitro):JKE-1674 reduces the viability of LOX-IMVI cancer cells with an EC50 of 0.03 μM and in a panel of additional cancer cell lines. JKE-1674 is completely rescued by ferroptosis inhibitors.(In Vivo):JKE-1674 (50?mg/kg; p.o.) could be detected in the serum of mice dosed orally with the compound.
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In VitroJKE-1674 exhibits activity indistinguishable from that of ML210 in cellular target engagement assays including yielding the same +434Da GPX4 adduct in cells. JKE-1674 kills LOX-IMVI cells in a manner that is equipotent to ML210 and is completely rescued by ferroptosis inhibitors. JKE-1674 forms a nitrile-oxide electrophile in cells. JKE-1674 dehydration yields a nitrile-oxide electrophile that binds GPX4. JKE-1674 exhibits far greater stability than chloroacetamide inhibitors.
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In VivoJKE-1674 (50?mg/kg; p.o.) can be detected in the serum of mice dosed orally with the compound. Animal Model:SCID mice Dosage:50?mg/kg (Pharmacokinetic Analysis)Administration:P.o.Result:Could be detected in the serum of mice dosed orally with the compound.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorIL-5
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Research Area——
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Indication——
Chemical Information
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CAS Number2421119-60-8
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Formula Weight451.3
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Molecular FormulaC20H20Cl2N4O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (221.58 mM)
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SMILESO=C(C(C[N+]([O-])=O)=NO)N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ian D Pavord, From DREAM to REALITI-A and beyond: Mepolizumab for the treatment of eosinophil-driven diseases. Allergy. 2022 Mar;77(3):778-797.
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