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JK-273
CAS No. 187723-38-2
JK-273( JK273 )
Catalog No. M12911 CAS No. 187723-38-2
A small molecule inhibitor of α4 integrin-dependent cell migration that functions by interacting with γ-parvin.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameJK-273
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NoteResearch use only, not for human use.
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Brief DescriptionA small molecule inhibitor of α4 integrin-dependent cell migration that functions by interacting with γ-parvin.
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DescriptionA small molecule inhibitor of α4 integrin-dependent cell migration (IC50=0.5 uM, on the motility of Jurkat T cells) that functions by interacting with γ-parvin; inhibits α4 integrin signaling, shows a selective cytotoxic effect against HCI-H460 NSCLC cells with IC50 of 0.98 uM, less sensitivity to fibroblasts (30-fold selectivity), causes cell cycle arrest at S phase and induces apoptosis.
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In Vitro——
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In Vivo——
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SynonymsJK273
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PathwayCell Cycle/DNA Damage
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TargetIntegrin
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RecptorIntegrin
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Research Area——
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Indication——
Chemical Information
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CAS Number187723-38-2
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Formula Weight335.795
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Molecular FormulaC18H14ClN5
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name6-(4-aminophenyl)-N-(3-chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lee J, et al. Bioorg Med Chem. 2009 Feb 1;17(3):977-80.
2. Lu TN, et al. Biochem Biophys Res Commun. 2017 Sep 16;491(2):355-360.
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