Cart
sales@molnova.com
Home - Products - Angiogenesis - JAK - JAK-IN-21

JAK-IN-21

CAS No. 2445499-20-5

JAK-IN-21( —— )

Catalog No. M35565 CAS No. 2445499-20-5

JAK-IN-21 is a selective and potent JAK inhibitor that inhibits JAK1, JAK2, J2V617F and TYK2 with IC50 values of 1.73, 2.04, 109 and 62.9 nM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 215 In Stock
10MG 328 In Stock
25MG 630 In Stock
50MG 768 In Stock
100MG 977 In Stock
200MG 1283 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    JAK-IN-21
  • Note
    Research use only, not for human use.
  • Brief Description
    JAK-IN-21 is a selective and potent JAK inhibitor that inhibits JAK1, JAK2, J2V617F and TYK2 with IC50 values of 1.73, 2.04, 109 and 62.9 nM, respectively.
  • Description
    JAK-IN-21 (Example 4) is a selective and potent JAK inhibitor with IC50s of 1.73, 2.04, 109 and 62.9 nM against JAK1, JAK2, J2V617F and TYK2, respectively.
  • In Vitro
    JAK-IN-21 (Example 4) doses not inhibit CYPs and shows good liver microsome stability.
  • In Vivo
    JAK-IN-21 (Example 4) shows low bioavailability (F=1.9%).Animal Model:SD rats Dosage:10 mg/kg Administration:Oral gavage (Pharmacokinetic Study).
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    JAK
  • Recptor
    JAK | Tyrosine Kinases
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2445499-20-5
  • Formula Weight
    372.38
  • Molecular Formula
    C19H16N8O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (335.68 mM; Ultrasonic )
  • SMILES
    CC=1C(=NC(NC2=CN(CC#N)N=C2)=NC1)C3=CC=C(C(NCC#N)=O)C=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhaokui WAN, et al. Benzamides of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof. Patent WO2020119819.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • CYT387

    A potent and selective JAK1/JAK2 inhibitor with IC50 of 11/18 nM.

  • Sweroside

    Sweroside is a promising osteoporosis therapeutic natural product, has anti-osteoporotic effect on the human MG-63 cells and rat osteoblasts.

  • Oclacitinib

    Oclacitinib(PF03394197) is a potent and selective JAKs inhibitor with IC50 of 10-99 nM.

Sign In Join Free