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Irisolidone

CAS No. 2345-17-7

Irisolidone( —— )

Catalog No. M24066 CAS No. 2345-17-7

Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Irisolidone
  • Note
    Research use only, not for human use.
  • Brief Description
    Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.
  • Description
    Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.
  • In Vitro
    Irisolidone, an isoflavone metabolite, represses JC virus gene expression via inhibition of Sp1 binding in human glial cells.Irisolidone can inhibit endothelial cell proliferation.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Chloride Channel
  • Recptor
    VRAC|IL Receptor|NF-Κb
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2345-17-7
  • Formula Weight
    314.29
  • Molecular Formula
    C17H14O6
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mM
  • SMILES
    O=C1C(C2=CC=C(OC)C=C2)=COC3=CC(O)=C(OC)C(O)=C13
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Natural and synthetic flavonoids, novel blockers of the volume-regulated anion channels, inhibit endothelial cell proliferation.Pflugers Arch. 2018 Jun 30.
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