Indazole-Cl( —— )

Catalog No. M34085 CAS No. 848142-62-1

Indazole-Cl is a selective ER? agonist and a selective estrogen receptor modifier (SERM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Indazole-Cl
Note

Research use only, not for human use.
Brief Description

Indazole-Cl is a selective ER? agonist and a selective estrogen receptor modifier (SERM).
Description

Indazole-Cl (Ind-Cl) is an Estrogen receptor (ER)-β-specific agonist with inflammatory effect. Indazole-Cl inhibits cyclooxygenase-2 exression reduction induced by hypoxia. And Indazole-Cl inhibits ROS production. Indazole-Cl also inhibits cell migration and invasion by hypoxia increased by hypoxia. Indazole-Cl is potent inhibitor of hypoxia-induced in?ammation in vascular smooth muscle cells (VSMCs).
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Endocrinology/Hormones
Target

Estrogen Receptor/ERR
Recptor

Estrogen/progestogen Receptor
Research Area

——
Indication

——

Chemical Information

CAS Number

848142-62-1
Formula Weight

260.68
Molecular Formula

C13H9ClN2O2
Purity

>98% (HPLC)
Solubility

——
SMILES

ClC=1N(N=C2C1C=C(O)C=C2)C3=CC=C(O)C=C3
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Park C, et al. Indazole-Cl inhibits hypoxia-induced cyclooxygenase-2 expression in vascular smooth muscle cells. J Mol Endocrinol. 2019 Jul 1;63(1):27-38. ?

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