InS3-54( —— )

Catalog No. M14082 CAS No. 328998-92-1

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Product Name

InS3-54
Note

Research use only, not for human use.
Brief Description

An STAT3 inhibitor that selectively targets the DNA-binding domain of STAT3.
Description

An STAT3 inhibitor that selectively targets the DNA-binding domain of STAT3, without affecting the activation and dimerization of STAT3; preferentially suppresses proliferation of cancer over non-cancer cells and inhibits migration and invasion of malignant cells; selectively inhibits STAT3 binding to DNA without affecting the activation and dimerization of STAT3; inhibits expression of STAT3 downstream target genes and STAT3 binding to chromatin in situ.
In Vitro

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In Vivo

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Synonyms

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Pathway

JAK/STAT Signaling
Target

STAT
Recptor

STAT
Research Area

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Indication

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CAS Number

328998-92-1
Formula Weight

412.401
Molecular Formula

C24H16N2O5
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

(E)-4-(3-(4-nitrobenzylidene)-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl)benzoic acid

1. Huang W, et al. ACS Chem Biol. 2014 May 16;9(5):1188-96. 2. Huang W, et al. Oncogene. 2016 Feb 11;35(6):783-92.

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