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INT-777

CAS No. 1199796-29-6

INT-777( —— )

Catalog No. M32967 CAS No. 1199796-29-6

INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 μM. INT-777 (S-EMCA) inhibits NLRP5-ASC inflammasome-mediated neuroinflammation via the TGR3/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 330 Get Quote
10MG 472 Get Quote
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Biological Information

  • Product Name
    INT-777
  • Note
    Research use only, not for human use.
  • Brief Description
    INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 μM. INT-777 (S-EMCA) inhibits NLRP5-ASC inflammasome-mediated neuroinflammation via the TGR3/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats.
  • Description
    INT-777 is a potent TGR5 agonist with an EC50 of 0.82 μM.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    GPCR19
  • Recptor
    GPCR19
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1199796-29-6
  • Formula Weight
    450.65
  • Molecular Formula
    C27H46O5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?Ethanol : ≥ 50 mg/mL (110.95 mM) DMSO : ≥ 31 mg/mL (68.79 mM)
  • SMILES
    [H][C@@]12CC[C@H]([C@H](C)C[C@H](C)C(O)=O)[C@@]1(C)[C@@H](O)C[C@@]1([H])[C@@]2([H])[C@H](O)[C@H](CC)[C@]2([H])C[C@H](O)CC[C@]12C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Pellicciari R, et al. Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity. J Med Chem. 2009 Dec 24;52(24):7958-61.?
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