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INCB3619
CAS No. 791826-72-7
INCB3619( —— )
Catalog No. M34284 CAS No. 791826-72-7
INCB3619 is a selective and potent inhibitor of ADAM with antitumour effects, inhibiting ADAM10, ADAM17, MMP12 and MMP15.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 296 | Get Quote |
|
| 5MG | 459 | Get Quote |
|
| 10MG | 657 | Get Quote |
|
| 25MG | 994 | Get Quote |
|
| 50MG | 1371 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameINCB3619
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NoteResearch use only, not for human use.
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Brief DescriptionINCB3619 is a selective and potent inhibitor of ADAM with antitumour effects, inhibiting ADAM10, ADAM17, MMP12 and MMP15.
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DescriptionINCB3619 is a selective and orally active ADAM inhibitor with IC50 of 22 nM and 14 nM for ADAM10 and ADAM17, respectively. INCB3619 has anti-tumor activity.
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In VitroApoptosis Analysis.Cell Line:A549 cell Concentration:1, 10 μM Incubation Time:Result:Induced about 3% apoptosis at a concentration of 1 μM and about 5% at a concentration of 10 μM.Cell Viability Assay.Cell Line:NCI-H1666 cell Concentration:0-10 μM Incubation Time:72 h Result:Inhibited proliferation of NCI-H1666 cells.
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In VivoAnimal Model:BALB/c nu/nu mouse model of A549 xenograft Dosage:50, 60 mg/kg Administration:subcutaneous injection, daily, 14 d Result:Significant tumor growth inhibition and delay at 60 mg/kg dose, less active effect at 50 mg/kg.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorImmunology/Inflammation related
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Research Area——
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Indication——
Chemical Information
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CAS Number791826-72-7
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Formula Weight413.47
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Molecular FormulaC22H27N3O5
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Purity>98% (HPLC)
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Solubility——
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SMILESC(NO)(=O)[C@H]1CC2(CN(C(OC)=O)[C@@H]1C(=O)N3CCC(=CC3)C4=CC=CC=C4)CC2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bin-Bing S Zhou, et al. Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer. Cancer Cell. 2006 Jul;10(1):39-50.?
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