ID-8( ID-8 | ID 8 | ID8 )

Catalog No. M18041 CAS No. 147591-46-6

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Product Name

ID-8
Note

Research use only, not for human use.
Brief Description

ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.
Description

ID-8 is a DYRK inhibitor. ID-8 could support Wnt-induced human embryonic stem cell proliferation and survival without differentiation. Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) is the target of the small molecule ID-8. Its role in human pluripotent cell renewal was confirmed by DYRK knockdown in human embryonic stem cells.
In Vitro

ID-8 (0.1-10 μM) increases human embryonic stem cell (hESC) survival.ID-8 (10 μM) stimulates ESCs proliferation in serum-free media for more than 1 month.
In Vivo

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Synonyms

ID-8 | ID 8 | ID8
Pathway

Others
Target

Other Targets
Recptor

DYRK
Research Area

Cancer
Indication

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1. Miyabayashi T, et al. Biosci Biotechnol Biochem. 2008 , 72(5), 1242-1248.

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