ICAM-1-IN-1

Research use only, not for human use.

ICAM-1-IN-1 is a potent and selective E-selectin(IC50 = 7 nM) and ICAM-1(IC50 = 5 nM) inhibitor.

ICAM-1-IN-1 is a potent and selective E-selectin(IC50 = 7 nM) and ICAM-1(IC50 = 5 nM) inhibitor.(In Vivo):In a rat rheumatoid arthritis model and in a mouse asthma model, ICAM-1-IN-1 shows significant efficacy. The width of inflamed ankles after the ninth day following treatment was reduced by ICAM-1-IN-1, but no efficacy was shown in the acute phase. Treatment with ICAM-1-IN-1 (25 mg/kg) for 21 days significantly reduced eosinophils, serum-soluble ICAM-1 (sICAM-1) and the ankle inflammation of the arthritis rats.

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ICAM-1-IN-1 shows significant efficacy in a rat rheumatoid arthritis model and in a mouse asthma model. ICAM-1-IN-1 reduces the width of inflamed ankles after the ninth day following treatment, but shows no efficacy in the acute phase. Treatment with ICAM-1-IN-1 (25 mg/kg) for 21 days significantly reduces the ankle inflammation of the arthritis rats. Significant reduction of eosinophils and serum-soluble ICAM-1 (sICAM-1) is observed.

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Cell Cycle/DNA Damage

Integrin

CDK4| CDK6

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251994-14-6

363.23

C15H11BrN2O2S

>98% (HPLC)

In Vitro:?DMSO : ≥ 135 mg/mL (371.67 mM)

CNC(=O)c1cc2c(Oc3ccc(Br)cc3)cncc2s1

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(-20℃)

With Ice Pack

≥ 2 years