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IACS-52825

CAS No. 2640376-72-1

IACS-52825( —— )

Catalog No. M37232 CAS No. 2640376-72-1

IACS-52825 is a selective and potent dual leucine zipper kinase (DLK) inhibitor that reverses para-mechanical aberrant pain in a CIPN mouse model for the study of neurological disorders.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 296 Get Quote
5MG 459 Get Quote
10MG 657 Get Quote
25MG 994 Get Quote
50MG 1371 Get Quote
100MG 1773 Get Quote
500MG Get Quote Get Quote
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Biological Information

  • Product Name
    IACS-52825
  • Note
    Research use only, not for human use.
  • Brief Description
    IACS-52825 is a selective and potent dual leucine zipper kinase (DLK) inhibitor that reverses para-mechanical aberrant pain in a CIPN mouse model for the study of neurological disorders.
  • Description
    IACS-52825 is a potent and selective DLK inhibitor with Kd of 1.3 nM, useful for the study of chemotherapy-induced peripheral neuropathy.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    DNA Alkylation
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2640376-72-1
  • Formula Weight
    426.29
  • Molecular Formula
    C16H13F7N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    [C@@H](C(F)(F)F)(O)C=1N(C23CC(F)(C2)C3)C=C(N1)C=4C=C(OC(F)(F)F)C(N)=NC4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kang Le, et al. Discovery of IACS-52825, a Potent and Selective DLK Inhibitor for Treatment of Chemotherapy-Induced Peripheral Neuropathy. J Med Chem. 2023 Jul 27;66(14):9954-9971. ?
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