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HaloPROTAC3
CAS No. 1799506-07-2
HaloPROTAC3( —— )
Catalog No. M34617 CAS No. 1799506-07-2
HaloPROTAC3 (HaloPROTAC-3) is a conjugate of ligands for E3 and 16-atom-length linker and a degrader of HaloTag fusion proteins.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 264 | In Stock |
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| 10MG | 432 | In Stock |
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| 25MG | 715 | In Stock |
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| 50MG | 986 | In Stock |
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| 100MG | 1330 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameHaloPROTAC3
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NoteResearch use only, not for human use.
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Brief DescriptionHaloPROTAC3 (HaloPROTAC-3) is a conjugate of ligands for E3 and 16-atom-length linker and a degrader of HaloTag fusion proteins.
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DescriptionVH285-PEG4-C4-Cl (HaloPROTAC 3) is a conjugate of ligands for E3 and 16-atom-length linker. The connector of linker is Halogen group. VH285-PEG4-C4-Cl incorporates the VH285 based VHL ligand and an alkyl/ether-based linker. VH285-PEG4-C4-Cl is a highly potent and efficacious degrader of GFP-HaloTag7 with a DC50 of 19 nM. VH285-PEG4-C4-Cl is able to induce 90 % degradation of GFP-Halotag at 625 nM. VH285-PEG4-C4-Cl binds to VHL with an IC50 of 0.54 μM.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayPROTACs
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TargetE3 Ligase Ligand
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RecptorLigand for E3 Ligase
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Research Area——
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Indication——
Chemical Information
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CAS Number1799506-07-2
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Formula Weight799.42
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Molecular FormulaC41H55ClN4O8S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (125.09 mM; Ultrasonic )
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SMILES[C@@H](C(=O)N1[C@H](C(NCC2=C(OCCOCCOCCOCCCCCCCl)C=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1)(C(C)C)N4C(=O)C=5C(C4)=CC=CC5
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10(8):1831-7.?
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