HTH-01-015( HTH 01 015 )

Catalog No. M12346 CAS No. 1613724-42-7

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Datasheet

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HPLC

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Product Name

HTH-01-015
Note

Research use only, not for human use.
Brief Description

HTH-01-015 is a potent, specific NUAK1 (AMPK-related kinase 5, ARK5) inhibitor with IC50 of 100 nM.
Description

HTH-01-015 is a potent, specific NUAK1 (AMPK-related kinase 5, ARK5) inhibitor with IC50 of 100 nM, displays >100-fold higher potency than NUAK2; also does not markedly suppress the activity of any of the other 139 protein kinases, including AMPK; suppresses NUAK1-mediated MYPT1 phosphorylation in vivo, the NUAK1 mutation (A195T) renders resistant to HTH-01-015; significantly inhibits migration the proliferation of MEFs (mouse embryonic fibroblasts).
In Vitro

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In Vivo

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Synonyms

HTH 01 015
Pathway

Membrane Transporter/Ion Channel
Target

AMPK
Recptor

NUAK1|NUAK2
Research Area

Cancer
Indication

——

CAS Number

1613724-42-7
Formula Weight

468.5535
Molecular Formula

C26H28N8O
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

CC1=C(N(C)C(C2=CC(C=CC=C3)=C3C=C2N4C)=O)C4=NC(NC5=CN(N=C5)C6CCNCC6)=N1
Chemical Name

6H-Naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one, 5,13-dihydro-4,5,13-trimethyl-2-[[1-(4-piperidinyl)-1H-pyrazol-4-yl]amino]-

1. Banerjee S, et al. Biochem J. 2014 Jan 1;457(1):215-25. 2. Banerjee S, et al. Biochem J. 2014 Jul 15;461(2):233-45.

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