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Gedatolisib
CAS No. 1197160-78-3
Gedatolisib( PF-05212384 | PKI-587 )
Catalog No. M10696 CAS No. 1197160-78-3
A highly potent, selective, dual PI3K/mTOR inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 41 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 110 | In Stock |
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| 25MG | 214 | In Stock |
|
| 50MG | 402 | In Stock |
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| 100MG | 597 | In Stock |
|
| 500MG | 1251 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGedatolisib
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NoteResearch use only, not for human use.
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Brief DescriptionA highly potent, selective, dual PI3K/mTOR inhibitor.
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DescriptionA highly potent, selective, dual PI3K/mTOR inhibitor with IC50 of 0.4/6/8/6/1.6 nM for PI3Kα/β/γ/δ/mTOR, respectively; also potently inhibits PI3Kα mutant H1047R and E545K with IC50 of 0.6 and 0.6 nM; prevents the pAkt at Thr 308 with IC50 of 8 nM, and suppresses pAkt S473 with IC50 of <10 nM in cells; demonstrates antitumor efficacy in both subcutaneous and orthotopic xenograft tumor models.Blood Cancer Phase 3 Clinical.
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In Vitro——
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In Vivo——
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SynonymsPF-05212384 | PKI-587
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptormTOR|PI3Kα|PI3Kγ
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number1197160-78-3
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Formula Weight615.72
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Molecular FormulaC32H41N9O4
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(NC1=CC=C(C2=NC(N3CCOCC3)=NC(N4CCOCC4)=N2)C=C1)NC5=CC=C(C(N6CCC(N(C)C)CC6)=O)C=C5
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Chemical Name1-(4-{[4-(Dimethylamino)-1-piperidinyl]carbonyl}phenyl)-3-{4-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]phenyl}urea
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Venkatesan AM, et al. J Med Chem. 2010 Mar 25;53(6):2636-45.
2. Mallon R, et al. Clin Cancer Res. 2011 May 15;17(10):3193-203.
3. Gedaly R, et al. J Surg Res. 2013 Nov;185(1):225-30.
4. D'Amato V, et al. Br J Cancer. 2014 Jun 10;110(12):2887-95.
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