Gamma-Methylleucine

Research use only, not for human use.

Gamma-Methylleucine is an auxiliary for copper-catalyzed asymmetric Michael reactions.

Gamma-Methylleucine is an auxiliary for copper-catalyzed asymmetric Michael reactions.(In Vivo):gamma-Methylleucine improved the binding affinity of the peptide for Y2R but also increased its anorectic activity in lean mice . Gamma-methylleucine resulted in loss of or significantly decreased the biological activity of ET-1, while high affinity for the ETA (IC50 = 0.42-0.70 nM) and ETB (IC50 = 0.17-0.43 nM) receptor was retained . Gamma-methylleucine was shown to have high antagonist activitiesin Sarafotoxin S6c-induced vasoconstriction of rabbit pulmonary artery (ET-1: pA2 8.4) and have the desirable characteristic of possessing no agonist activity at either receptor subtype .

gamma-Methyl-L-leucine; L-Neopentylglycine; 2-Amino-3-tert-butylpropionic acid

Others

Other Targets

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57224-50-7

145.2

C7H15NO2

>98% (HPLC)

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CC(C)(C)C[C@H](N)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years