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GW297361
CAS No. 388627-21-2
GW297361( —— )
Catalog No. M36628 CAS No. 388627-21-2
GW297361 is a potent inhibitor of the cell cycle protein-dependent kinase Cdk1 and also inhibits the Pho85 signaling pathway.The IC50s of GW297361 on yeast Cdk1 and Pho85 were 20 nM and 400 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 375 | Get Quote |
|
| 5MG | 588 | Get Quote |
|
| 10MG | 885 | Get Quote |
|
| 25MG | 1362 | Get Quote |
|
| 50MG | 1822 | Get Quote |
|
| 100MG | 2457 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameGW297361
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NoteResearch use only, not for human use.
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Brief DescriptionGW297361 is a potent inhibitor of the cell cycle protein-dependent kinase Cdk1 and also inhibits the Pho85 signaling pathway.The IC50s of GW297361 on yeast Cdk1 and Pho85 were 20 nM and 400 nM, respectively.
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DescriptionGW297361 is an oxindole CDK inhibitor that elicits a Pho85-selective response in cells. GW297361 inhibits yeast Cdk1 and Pho85 with IC50s of 20 nM and 400 nM in vitro, respectively.
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In VitroWestern Blot Analysis Cell Line:YRP1 cells Concentration:20 μM Incubation Time:20 μM Result:An intermediate level of the Orc6 was converted to the faster-migrating isoform (lower:upper = 2:1).
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetVEGFR
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RecptorVEGFR | Src | CDK
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Research Area——
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Indication——
Chemical Information
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CAS Number388627-21-2
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Formula Weight372.42
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Molecular FormulaC16H12N4O3S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (268.51 mM; Ultrasonic )
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SMILESC(NC1=CC=C(S(N)(=O)=O)C=C1)=C2C=3C4=C(C=CC3NC2=O)N=CS4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kung C, et al. Selective kinase inhibition by exploiting differential pathway sensitivity. Chem Biol. 2006 Apr;13(4):399-407.?
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