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GW-803430
CAS No. 515141-51-2
GW-803430( —— )
Catalog No. M33378 CAS No. 515141-51-2
GW-803430 (GW-3430) is an orally active and selective melanin-concentrating hormone receptor 1 (MCH R1) antagonist used in the study of obesity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 88 | In Stock |
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| 5MG | 140 | In Stock |
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| 10MG | 250 | In Stock |
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| 25MG | 514 | In Stock |
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| 50MG | 717 | In Stock |
|
| 100MG | 945 | In Stock |
|
| 200MG | 1278 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGW-803430
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NoteResearch use only, not for human use.
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Brief DescriptionGW-803430 (GW-3430) is an orally active and selective melanin-concentrating hormone receptor 1 (MCH R1) antagonist used in the study of obesity.
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DescriptionGW-803430 (GW-3430) is a potent and selective melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pIC50 of 9.3. GW-803430 is orally active in an animal model of obesity.
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In VitroGW-803430 demonstrates a potent antagonist activity towards MCH induced MCHR1 receptor with an IC50 value of ~13?nM.
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In VivoGW-803430 (0.3, 3, and 15 mg/kg; oral administration; once daily) causes a sustained dose-dependent weight loss relative to vehicle controls.GW-803430 is a suitable compound for its good pharmacokinetic properties (bioavailability=31%, t1/2=11 h) and brain penetration (6:1 brain:plasma concentration) in mice.Animal Model:High fat diet-induced obese AKR/J mice Dosage:0.3, 3, and 15 mg/kg Administration:Orally, qd,12 days Result:Caused a sustained dose-dependent weight loss of -6.2%, -12.1%, and -13.1%, respectively, relative to vehicle controls.
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Synonyms——
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PathwayGPCR/G Protein
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TargetMCHR
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RecptorMelanin-concentrating Hormone Receptor (MCHR)
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Research Area——
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Indication——
Chemical Information
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CAS Number515141-51-2
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Formula Weight481.99
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Molecular FormulaC25H24ClN3O3S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1C=2SC(=CC2N=CN1C3=CC=C(OCCN4CCCC4)C(OC)=C3)C=5C=CC(Cl)=CC5
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hertzog DL, et al. The discovery and optimization of pyrimidinone-containing MCH R1 antagonists. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4723-7.?
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