GSK983( GSK-983 | GSK 983 )

Catalog No. M16075 CAS No. 827591-02-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

GSK983
Note

Research use only, not for human use.
Brief Description

GSK983 (GSK-983) is a potent, cell penetrant PCAF/GCN5 PROTAC, induces concentration-dependent degradation of PCAF and GCN5 in THP1 cells with DC50 value of 1.5 nM and 3 nM, respectively.
Description

GSK983 (GSK-983) is a potent, cell penetrant PCAF/GCN5 PROTAC, induces concentration-dependent degradation of PCAF and GCN5 in THP1 cells with DC50 value of 1.5 nM and 3 nM, respectively; also potently induces robust and concentration-dependent degradation of PCAF and GCN5 in both macrophages and monocyte-derived dendritic cells (DCs), potently modulate the expression of multiple inflammatory mediators in LPS-stimulated macrophages and dendritic cells.
In Vitro

RT-PCR Cell Line:W12, HKC cells Concentration:10, 100 nM Incubation Time:24, 48 h Result:Induced the expression of interferon-stimulated genes in infected and immortalized cells, increased the gene expression of CSF2, IFIT1 (ISG56), IL6, ISG15, OAS1, OAS2, OASL and TNFSF10 (TRAIL).
In Vivo

——
Synonyms

GSK-983 | GSK 983
Pathway

PROTACs
Target

PROTAC
Recptor

PROTAC
Research Area

——
Indication

——

CAS Number

827591-02-6
Formula Weight

895.856
Molecular Formula

C45H51BrN8O7
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : ≥ 10 mg/mL (30.69 mM)
SMILES

O=C(N[C@H]1C(NC2=C3C=C(Cl)C=C2)=C3CCC1)C4=NC=CC=C4
Chemical Name

4-(5-((5-bromo-1-methyl-6-oxo-1,6-dihydropyridazin-4-yl)amino)-1-methylpiperidin-3-yl)-N-(3-((4-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)propyl)phenyl)(methyl)amino)propyl)-N-methylbenzamide

1. Bassi ZI, et al. ACS Chem Biol. 2018 Oct 19;13(10):2862-2867.

Calculator

molnova catalog