GSK-583( GSK583 | GSK 583 )

Catalog No. M11400 CAS No. 1346547-00-9

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Product Name

GSK-583
Note

Research use only, not for human use.
Brief Description

A potent, selective and orally bioavailable RIPK2 kinase inhibitor with IC50 of 5 nM and 2 nM for human and rat RIP2, respectively.
Description

A potent, selective and orally bioavailable RIPK2 kinase inhibitor with IC50 of 5 nM and 2 nM for human and rat RIP2, respectively; displays robust selectivity against p38α and VEGFR2, and shows little or no inhibition of RIP3-dependent necroptotic cell death; potently and dose dependently inhibits MDP-stimulated TNFα production in human monocytes and human whole bolld with IC50 of 8 nM and 237 nM, respectively; inhibits MDP-induced inflammatory responses in vivo.
In Vitro

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In Vivo

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Synonyms

GSK583 | GSK 583
Pathway

Apoptosis
Target

RIP kinase
Recptor

RIP1|RIP3
Research Area

Inflammation/Immunology
Indication

——

CAS Number

1346547-00-9
Formula Weight

398.4539
Molecular Formula

C20H19FN4O2S
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 37 mg/mL
SMILES

FC1=CC2=C(NN=C2NC3=CC=NC4=CC=C(S(=O)(C(C)(C)C)=O)C=C34)C=C1
Chemical Name

4-Quinolinamine, 6-[(1,1-dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-

1. Haile PA, et al. J Med Chem. 2016 May 26;59(10):4867-80.

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