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GS-9901
CAS No. 1640247-87-5
GS-9901( —— )
Catalog No. M33371 CAS No. 1640247-87-5
GS-9901 is a selective, orally active and potent PI3Kδ inhibitor (IC50: 1 nM) for the study of non-Hodgkin's lymphoma and chronic lymphocytic leukemia.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 128 | Get Quote |
|
| 5MG | 188 | Get Quote |
|
| 10MG | 330 | Get Quote |
|
| 25MG | 685 | Get Quote |
|
| 50MG | 908 | Get Quote |
|
| 100MG | 1233 | Get Quote |
|
| 500MG | 2484 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameGS-9901
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NoteResearch use only, not for human use.
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Brief DescriptionGS-9901 is a selective, orally active and potent PI3Kδ inhibitor (IC50: 1 nM) for the study of non-Hodgkin's lymphoma and chronic lymphocytic leukemia.
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DescriptionGS-9901 is a highly selective and orally active PI3Kδ inhibitor, with an IC50 of 1 nM. Has potential to treat rheumatoid arthritis.
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In Vitro——
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In VivoGS-9901 (0.3/1/3 mg/kg, orally,twice daily for 7 days) demonstrates efficacy in a rat model of arthritis and is predicted to be suitable for q.d. dosing in humans.Animal Model:Female Lewis rats with established collagen-induced arthritis (CIA).Dosage:0.3 mg/kg, 1 mg/kg, and 3 mg/kg.Administration:Orally, twice-daily for 7 days starting on the 10th day after the second collagen immunization.Result:Demonstrated significant reduction in ankle swelling in rats treated with 0.3 mg/kg 35 (31% reduction), 1 mg/kg 35 (67%), and 3 mg/kg 35 (65%). Plasma concentrations measured on day 7 (12 h after last dose) were consistent with maintaining approximately 60%, 80%, and >90% inhibition of PI3Kδ at 0.3, 1.0, and 3 mg/kg doses, respectively, at trough levels.
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Synonyms——
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3K
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Research Area——
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Indication——
Chemical Information
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CAS Number1640247-87-5
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Formula Weight477.88
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Molecular FormulaC22H17ClFN9O
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Purity>98% (HPLC)
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Solubility——
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SMILES[C@@H](NC=1C(C#N)=C(N)N=C(N)N1)(C=2N(C(=O)C=3C(N2)=C(F)C=CC3Cl)C=4C=CC=NC4)C5CC5
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Patel L, et al. Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ Inhibitors with Improved Metabolic Stability. J Med Chem. 2016 Oct 13;59(19):9228-9242.?
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