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GNE-317
CAS No. 1394076-92-6
GNE-317( GNE317 )
Catalog No. M11644 CAS No. 1394076-92-6
GNE-317 (GNE317) is a potent, brain penepenetrant, dual PI3K/mTOR inhibitor having physicochemical properties predictive of low efflux by P-gp and BCRP.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 42 | In Stock |
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| 5MG | 68 | In Stock |
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| 10MG | 110 | In Stock |
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| 25MG | 200 | In Stock |
|
| 50MG | 331 | In Stock |
|
| 100MG | 410 | In Stock |
|
| 200MG | 601 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGNE-317
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NoteResearch use only, not for human use.
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Brief DescriptionGNE-317 (GNE317) is a potent, brain penepenetrant, dual PI3K/mTOR inhibitor having physicochemical properties predictive of low efflux by P-gp and BCRP.
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DescriptionGNE-317 (GNE317) is a potent, brain penepenetrant, dual PI3K/mTOR inhibitor having physicochemical properties predictive of low efflux by P-gp and BCRP; inhibits the cell proliferation of GBM6, 10, 22, and 84 with IC50 of 0.59, 0.72, 0.26, and 3.49 uM, respectively; markedly inhibits the PI3K pathway in mouse brain, causing 40% to 90% suppression of the pAkt and pS6 signals, significantly inhibits tumor growth in orthotopic models of glioblastoma multiforme (GBM).
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In Vitro——
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In Vivo——
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SynonymsGNE317
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3K
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1394076-92-6
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Formula Weight414.4814
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Molecular FormulaC19H22N6O3S
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Purity>98% (HPLC)
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SolubilityDMSO: 20 mg/mL
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SMILESNC1=NC=C(C2=NC(N3CCOCC3)=C4C(C=C(C5(OC)COC5)S4)=N2)C=N1
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Chemical Name2-Pyrimidinamine, 5-[6-(3-methoxy-3-oxetanyl)-7-methyl-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Salphati L, et al. Clin Cancer Res. 2012 Nov 15;18(22):6239-48.
2. Lewis Phillips GD, et al. Breast Cancer Res Treat. 2017 Aug;164(3):581-591.
3. Becker CM, et al. Neuro Oncol. 2015 Sep;17(9):1210-9.
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