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Fluorofenidone

CAS No. 848353-85-5

Fluorofenidone( AKF-PD )

Catalog No. M26688 CAS No. 848353-85-5

Fluorofenidone attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Fluorofenidone
  • Note
    Research use only, not for human use.
  • Brief Description
    Fluorofenidone attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway.
  • Description
    Fluorofenidone attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway. Fluorofenidone is an analogue of AMR69. Which displays equivalent lower toxicity, antifibrotic activity, and longer half-life.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    AKF-PD
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    848353-85-5
  • Formula Weight
    203.216
  • Molecular Formula
    C12H10FNO
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 140 mg/mL (688.94 mM)
  • SMILES
    Cc1ccc(=O)n(c1)-c1cccc(F)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Shi J, et al. Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation. Drug Metab Dispos. 2016 Apr;44(4):554-9.
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