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Fluorizoline
CAS No. 1362243-70-6
Fluorizoline( —— )
Catalog No. M34601 CAS No. 1362243-70-6
Fluorizoline is a PHB-binding compound with anticancer and antiproliferative activity that induces apoptosis by inducing selective targeting of the BH3 protein NOXA to PHB.Fluorizoline inhibits protein synthesis and has been used in studies of leukemia.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameFluorizoline
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NoteResearch use only, not for human use.
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Brief DescriptionFluorizoline is a PHB-binding compound with anticancer and antiproliferative activity that induces apoptosis by inducing selective targeting of the BH3 protein NOXA to PHB.Fluorizoline inhibits protein synthesis and has been used in studies of leukemia.
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DescriptionFluorizoline selectively and directly binds to prohibitin 1 (PHB1) and 2 (PHB2), and induces apoptosis. Fluorizoline reduces chronic lymphocytic leukemia (CLL) cell viability through the upregulation of NOXA and BIM. Fluorizoline exerts antitumor action in a p53-independent manner.
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In VitroApoptosis Analysis Cell Line:Primary CLL cells Concentration:1.25 to 20 μM Incubation Time:24 hours Result:Strongly reduced cell viability and induced apoptosis in a dose-dependent manner.Western Blot Analysis Cell Line:Primary CLL cells Concentration:5, 10 μM Incubation Time:48 hours Result:Caused an increase of NOXA protein levels.
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number1362243-70-6
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Formula Weight362.2
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Molecular FormulaC15H8Cl2F3NS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (138.05 mM; Ultrasonic )
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SMILESFC1(F)N=C(SC1(F)c1ccc(Cl)cc1)c1ccc(Cl)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ana M Cosialls, et al. The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax. Haematologica. 2017 Sep;102(9):1587-1593.?
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