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Faropenem

CAS No. 106560-14-9

Faropenem( —— )

Catalog No. M10283 CAS No. 106560-14-9

Faropenem is an orally active beta-lactam antibiotic with broad-spectrum antibacterial activity against many gram-positive and gram-negative aerobes and anaerobes.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Faropenem
  • Note
    Research use only, not for human use.
  • Brief Description
    Faropenem is an orally active beta-lactam antibiotic with broad-spectrum antibacterial activity against many gram-positive and gram-negative aerobes and anaerobes.
  • Description
    Faropenem is an orally active beta-lactam antibiotic with broad-spectrum antibacterial activity against many gram-positive and gram-negative aerobes and anaerobes; has improved chemical stability and reduced central nervous system effects compared with imipenem.Bacterial Infection Launched.
  • In Vitro
    Faropenem is not active against methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, Pseudomonas aeruginosa or Stenotrophomonas maltophilia.Faropenem is against all isolates?of?B. anthracis.?The MIC values ranged from ≤0.06 to >64 μg/liter, and the MIC90?value is 0.5 μg/ml. The MIC90?value for Faropenem is lower than that observed for other β-lactams, such as Meropenem, Amoxicillin-clavulanate, and Penicillin, for which the MIC90?values are 4 μg/ml, 4 μg/ml, and 8 μg/ml, respectively.
  • In Vivo
    Faropenem ( i.p. at 24 h postchallenge at 4-, 6-, and 12-h intervals; 10, 20, 40, and 80 mg/kg/day; 14 days) demonstrates a high level of activity against B. anthracis in the murine post-exposure prophylaxis inhalation model.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Antibacterial
  • Research Area
    Infection
  • Indication
    Bacterial Infection

Chemical Information

  • CAS Number
    106560-14-9
  • Formula Weight
    285.317
  • Molecular Formula
    C12H15NO5S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C1C2N(C1=O)C(=C(S2)C3CCCO3)C(=O)O)O
  • Chemical Name
    (5R,6S)-6-[(1R)-1-Hydroxyethyl]-7-oxo-3-[(2R)-tetrahydro-2-furanyl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sato K, et al. J Antimicrob Chemother. 1999 Sep;44(3):337-41. 2. Hikida M, et al. Antimicrob Agents Chemother. 1999 Aug;43(8):2010-6. 3. Critchley IA, et al. Antimicrob Agents Chemother. 2002 Feb;46(2):550-5.
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