Fargesin( Fargesin )

Catalog No. M18407 CAS No. 31008-19-2

Fargesin as a potential β1AR antagonist through cAMP/PKA pathway could protect against myocardial ischemia/reperfusion injury in rats.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Fargesin
Note

Research use only, not for human use.
Brief Description

Fargesin as a potential β1AR antagonist through cAMP/PKA pathway could protect against myocardial ischemia/reperfusion injury in rats.
Description

Fargesin is a lignan from Magnolia fargesii, an oriental medicine used in the treatment of nasal congestion and sinusitis. Fargesin exhibits anti-inflammation effects on THP-1 cells via suppression of PKC pathway including downstream JNK, nuclear factors AP-1 and NF-?B. Fargesin as a potential β? adrenergic receptor antagonist protects the hearts against ischemia/reperfusion injury in rats via attenuating oxidative stress and apoptosis.(In Vitro):Fargesin exhibits anti-inflammation effects on THP-1 cells via suppression of PKC pathway including downstream JNK, nuclear factors AP-1 and NF-?B.Fargesin as a potential β? adrenergic receptor antagonist protects the hearts against ischemia/reperfusion injury in rats via attenuating oxidative stress and apoptosis.(In Vivo):Fargesin has antihypertensive effect in 2K1C hypertensive rats via inhibiting oxidative stress and promoting NO release.
In Vitro

Fargesin exhibits anti-inflammation effects on THP-1 cells via suppression of PKC pathway including downstream JNK, nuclear factors AP-1 and NF-?B. Fargesin as a potential β? adrenergic receptor antagonist protects the hearts against ischemia/reperfusion injury in rats via attenuating oxidative stress and apoptosis.
In Vivo

Fargesin has antihypertensive effect in 2K1C hypertensive rats via inhibiting oxidative stress and promoting NO release.
Synonyms

Fargesin
Pathway

Angiogenesis
Target

VEGFR
Recptor

β1-adrenergic receptor
Research Area

——
Indication

——

Chemical Information

CAS Number

31008-19-2
Formula Weight

370.4
Molecular Formula

C21H22O6
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (337.47 mM)
SMILES

COC1=C(C=C(C=C1)C2C3COC(C3CO2)C4=CC5=C(C=C4)OCO5)OC
Chemical Name

1H,3H-Furo(3,4-C)furan, 1alpha-(3,4-dimethoxyphenyl)-3abeta,4,6,6abeta-tetrahydro-4beta-((3,4-methylenedioxy)phenyl)-