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FSLLRY-NH2
CAS No. 245329-02-6
FSLLRY-NH2( —— )
Catalog No. M30691 CAS No. 245329-02-6
Selective PAR2 peptide antagonist. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduces symptoms in a mouse model of dermatophyte-associated itch.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameFSLLRY-NH2
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NoteResearch use only, not for human use.
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Brief DescriptionSelective PAR2 peptide antagonist. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduces symptoms in a mouse model of dermatophyte-associated itch.
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DescriptionSelective PAR2 peptide antagonist. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduces symptoms in a mouse model of dermatophyte-associated itch.
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In Vitro——
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In VivoTreatment with FSLLRY-NH2 (50 μg per rat administered intranasally at 1 hour postresuscitation) significantly improves neurological outcome and reduces the number of degenerating hippocampal neurons after ACA (asphyxial CA).
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Synonyms——
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PathwayGPCR/G Protein
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TargetPAR
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number245329-02-6
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Formula Weight796.97
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Molecular FormulaC39H60N10O8
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Purity>98% (HPLC)
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Solubilitywater:1 mg/mL
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SMILES[H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. McLarty et al (2011) Tryptase/protease-activated receptor 2 interactions induce selective mitogen-activated protein kinase signaling and collagen synthesis by cardiac fibroblasts. Hypertension 58 264 PMID:
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FSLLRY-NH2
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