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Etiocholanone
CAS No. 53-42-9
Etiocholanone( —— )
Catalog No. M24515 CAS No. 53-42-9
Etiocholanolone (5β-Androsterone) is the excreted?metabolite?of testosterone and has anticonvulsant activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 49 | In Stock |
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| 5MG | 60 | In Stock |
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| 10MG | 90 | In Stock |
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| 25MG | 163 | In Stock |
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| 50MG | 245 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameEtiocholanone
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NoteResearch use only, not for human use.
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Brief DescriptionEtiocholanolone (5β-Androsterone) is the excreted?metabolite?of testosterone and has anticonvulsant activity.
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DescriptionEtiocholanolone (5β-Androsterone) is the excreted?metabolite?of testosterone and has anticonvulsant activity. Etiocholanolone is a less potent?neurosteroid positive allosteric modulator?(PAM) of the?GABAA?receptor than its?enantiomer form.
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In VitroEtiocholanolone (10 μM) coapplication with GABA leads to an increase in the relative frequency of long openings (fraction of OT3, site A2 effect), but it isineffective at increasing the duration of long openings (site B effect) or at decreasing the relative frequency of the activation-related closed time component (site A1 effect).
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In VivoEtiocholanolone (intraperitoneal injection; 0-109.1 mg/kg; single dose) exhibits ED50?values of 57.6 and 109.1 mg/kg in the 6-Hz and PTZ tests, respectively. Protective activity in the 6-Hz test of 5β,3α-A persists for 2 h and is shorter than ent-5β,3α-A treatment (3 hours) in mice.
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetOther Targets
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RecptorGABAA
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Research Area——
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Indication——
Chemical Information
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CAS Number53-42-9
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Formula Weight290.44
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Molecular FormulaC19H30O2
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Purity>98% (HPLC)
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SolubilityDMSO:97 mg/mL?(333.97 mM;?Need ultrasonic)
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SMILESC[C@](CC1)([C@@H](CC2)[C@H](CC3)[C@H]1[C@@](C)(CC1)[C@H]3C[C@@H]1O)C2=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ping Li,et al. Natural and Enantiomeric Etiocholanolone Interact With Distinct Sites on the Rat alpha1beta2gamma2L GABAA Receptor. Mol Pharmacol. 2007 Jun;71(6):1582-90.
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