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Enerisant

CAS No. 1152747-82-4

Enerisant( —— )

Catalog No. M36010 CAS No. 1152747-82-4

Enerisant (TS-091) is an orally active, selective and potent histamine H3 receptor antagonist that modulates histamine H3 receptors in mice in a dose-dependent manner.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 149 Get Quote
5MG 216 Get Quote
10MG 347 Get Quote
25MG 707 Get Quote
50MG 1132 Get Quote
100MG 1773 Get Quote
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Biological Information

  • Product Name
    Enerisant
  • Note
    Research use only, not for human use.
  • Brief Description
    Enerisant (TS-091) is an orally active, selective and potent histamine H3 receptor antagonist that modulates histamine H3 receptors in mice in a dose-dependent manner.
  • Description
    Enerisant (TS-091) is a potent, highly selective, competitive and orally active histamine H3 receptor antagonist/inverse agonist with IC50s of 2.89 nM and 14.5 nM against human and rat histamine H3 receptors, respectively.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male SD rats, R-α-methylhistamine-induced dipsogenia model Dosage:0.1, 0.3 and 1 mg/kg Administration:Oral, single dose Result:Attenuated the dipsogenia response, reaching statistical significance at doses of 0.3 mg/kg and 1 mg/kg.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Histamine Receptor
  • Recptor
    Histamine Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1152747-82-4
  • Formula Weight
    398.5
  • Molecular Formula
    C22H30N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (250.94 mM; Ultrasonic )
  • SMILES
    C(=O)(C1=CN(N=C1)C2=CC=C(OCCCN3[C@H](C)CCC3)C=C2)N4CCOCC4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hino N, et al. A novel potent and selective histamine H3 receptor antagonist enerisant: in vitro profiles, in vivo receptor occupancy, and wake-promoting and procognitive effects in rodents. Journal of Pharmacology and Experimental Therapeutics, 2020, 375(2): 276-285.
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