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ERDRP-0519

CAS No. 1374006-96-8

ERDRP-0519( —— )

Catalog No. M33982 CAS No. 1374006-96-8

ERDRP-0519 is an orally bioavailable small-molecule inhibitor of the Measles virus (MeV) polymerase.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 330 Get Quote
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Biological Information

  • Product Name
    ERDRP-0519
  • Note
    Research use only, not for human use.
  • Brief Description
    ERDRP-0519 is an orally bioavailable small-molecule inhibitor of the Measles virus (MeV) polymerase.
  • Description
    ERDRP-0519, an orally bioavailable small-molecule Measles virus (MeV) polymerase inhibitor, prevents measles disease in squirrel monkeys (Saimiri sciureus). ERDRP-0519 inhibits morbilliviruses with nanomolar potency..
  • In Vitro
    ERDRP-0519 exhibits potency against a panel of Measles virus (MeV) isolates with EC50s of 0.07- 0.3 μM. ERDRP-0519 exhibits potency against MeV and related pathogens of the?Morbillivirus?genus, such as canine distemper virus (CDV).
  • In Vivo
    A single-dose pharmacokinetic (PK) study is performed in squirrel monkeys by oral (intragastric) delivery of ERDRP-0519 (50?mg/kg) and blood sampling at seven predefined time points after dosing. Serum concentrations peak ~2?h post-administration (Cmax=3.27?μM).
  • Synonyms
    ——
  • Pathway
    Immunology/Inflammation
  • Target
    Antiviral
  • Recptor
    Antiviral
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1374006-96-8
  • Formula Weight
    529.58
  • Molecular Formula
    C23H30F3N5O4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (188.83 mM; Ultrasonic )
  • SMILES
    Cn1nc(cc1C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCCC[C@H]1CCN1CCOCC1)C(F)(F)F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Stefanie A Krumm, et al. An orally available, small-molecule polymerase inhibitor shows efficacy against a lethal morbillivirus infection in a large animal model. Sci Transl Med.?2014 Apr 16;6(232):232ra52.?
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