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EP009
CAS No. 1462951-30-9
EP009( EP-009 | EP 009 )
Catalog No. M11987 CAS No. 1462951-30-9
A selective, orally active JAK3 inhibitor that reduces IL-2-mediated JAK3 tyrosine phosphorylation with cellular IC50 of 10-20 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameEP009
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NoteResearch use only, not for human use.
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Brief DescriptionA selective, orally active JAK3 inhibitor that reduces IL-2-mediated JAK3 tyrosine phosphorylation with cellular IC50 of 10-20 uM.
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DescriptionA selective, orally active JAK3 inhibitor that reduces IL-2-mediated JAK3 tyrosine phosphorylation with cellular IC50 of 10-20 uM; exhibits limited off-target effects against a panel of 92 human kinases; inhibits tyrosine phosphorylation and activation of JAK3/STAT3 in SU-DHL-1 cells, with activation of JNK1/2, but not p38; displays a favorable cytotoxicity profile with therapeutic efficacy against JAK3-driven tumor T-cells in vitro, in vivo, and ex vivo.
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In Vitro——
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In Vivo——
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SynonymsEP-009 | EP 009
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PathwayAngiogenesis
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TargetJAK
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RecptorJAK
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Research Area——
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Indication——
Chemical Information
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CAS Number1462951-30-9
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Formula Weight224.344
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Molecular FormulaC14H24O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1C(CO)CCCCCCCCCC1=C
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Chemical Name2-(hydroxymethyl)-12-methylenecyclododecanone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ross JA, et al. Leukemia. 2014 Apr;28(4):941-4.
2. Martinez GS, et al. Clin Cancer Drugs. 2016;3(2):131-137.
molnova catalog
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