Dynole 34-2

Research use only, not for human use.

Dynole 34-2 is a potent dynamin GTPase inhibitor with IC50 of 6.9 and 14.2 uM for full-length dynI and dynII GTPase activity, respectively.

Dynole 34-2 is a potent dynamin GTPase inhibitor with IC50 of 6.9 and 14.2 uM for full-length dynI and dynII GTPase activity, respectively; induces cytokinesis failure at the point of abscission, consistent with inhibition of dynamin while not affecting other cell cycle stages in cancer cells; disrupt midbody localization of calcineurin but not phospho-dynII and γ-tubulin, inhibits growth in a range of cancer cell lines with IC50 of 4.0 to 36.7 uM in MTT assays; Dynole 34-2 is a novel antimitotic compound acting specifically at the abscission stage.

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Cytoskeleton/Cell Adhesion Molecules

Dynamin

Dynamin

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1128165-88-7

408.59

C25H36N4O

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (244.75 mM)

CCCCCCCCNC(=O)C(=CC1=CN(C2=CC=CC=C21)CCCN(C)C)C#N

2-Cyano-3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-N-octyl-2-propenamide

(-20℃)

With Ice Pack

≥ 2 years