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Dooku1

CAS No. 2253744-54-4

Dooku1( —— )

Catalog No. M26169 CAS No. 2253744-54-4

Dooku1 is an analog of Yoda1 and a selective antagonist of endogenous Piezo1 channels.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Dooku1
  • Note
    Research use only, not for human use.
  • Brief Description
    Dooku1 is an analog of Yoda1 and a selective antagonist of endogenous Piezo1 channels.
  • Description
    Dooku1 is an analog of Yoda1 and a selective antagonist of endogenous Piezo1 channels. Dooku1 inhibits Ca2+ entry induced by 2μMYoda1 with IC50 values of 1.3μM (in HEK 293 cells) and 1.5μM (in HUVEC). Dooku1 inhibits Yoda1-induced aortic relaxation.
  • In Vitro
    Cell Viability Assay Cell Line:HUVECs, Piezo1 T-REx cells Concentration:10 μM Incubation Time:40-60 s Result:Had a concentration-dependent inhibitory effect against Yoda1-induced Ca2+ entry in HUVECs, acting with an IC50 of 1.49 μM.Increased potency in HUVECs with an EC50 of 0.23 μM, compared with 2.51 μM in Piezo1 T-REx cells.
  • In Vivo
    Animal Model:wild-type male C57BL/6 mice’s aortic rings Dosage:10 μM Administration:20 min Result:Suppressed the Yoda1-induced relaxation.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Bacterial
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2253744-54-4
  • Formula Weight
    326.2
  • Molecular Formula
    C13H9Cl2N3OS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (306.56 mM)
  • SMILES
    Clc1cccc(Cl)c1CSc1nnc(o1)-c1ccc[nH]1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Alois Pískala, et al. Synthesis, molecular conformation and biological activity of 6-amino-5-azacytidine. Collect. Czech. Chem. Commun. 1989, 54, 2502-2512.
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