Dantrolene

Research use only, not for human use.

Dantrolene is a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.

Dantrolene is a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.

RT-PCR Cell Line:Porcine aortic valvular interstitial cells (paVICs) Concentration:60 μM Incubation Time:At 1 and 3 days Result:Significantly inhibited ACTA2 expression and upregulated RUNX2 expression.

Animal Model:YAC128 transgenic mice (FVBN/NJ background strain) and WT mice Dosage:5 mg/kg Administration:Fed orally twice per week from 2 to 11.5 months of age Result:Resulted in significantly improved performance in the beam-walking and gait-walking assays. Significantly reduced the loss of NeuN-positive striatal neurons and reduced formation of Httexp nuclear aggregates.

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Others

Other Targets

Ryanodine receptor

Cerebrovascular system

Subarachnoid HemorrhageCerebral Vasospasm

7261-97-4

314.25

C14H10N4O5

>98% (HPLC)

In Vitro:?DMSO : ≥ 20 mg/mL (63.64 mM)

[O-][N+](=O)c1ccc(cc1)-c1ccc(C=NN2CC(=O)NC2=O)o1

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(-20℃)

With Ice Pack

≥ 2 years