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DMH-1
CAS No. 1206711-16-1
DMH-1( DMH1 | DMH 1 )
Catalog No. M10757 CAS No. 1206711-16-1
DMH1 is a potent, selective bone morphogenetic protein receptor (BMP) inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 48 | In Stock |
|
| 10MG | 76 | In Stock |
|
| 25MG | 147 | In Stock |
|
| 50MG | 262 | In Stock |
|
| 100MG | 410 | In Stock |
|
| 500MG | 888 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDMH-1
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NoteResearch use only, not for human use.
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Brief DescriptionDMH1 is a potent, selective bone morphogenetic protein receptor (BMP) inhibitor.
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DescriptionDMH1 is a potent, selective bone morphogenetic protein receptor (BMP) inhibitor with IC50 of 27/107.9/<5/47.6 nM for ALK1/ALK2/ALK3/ALK6, respectively; significantly reduces the percentage of cells expressing the pluripotency marker proteins OCT4 and Nanog in both SM3 and CA6 cells, induces regulation of pluripotency and neural precursor marker mRNAs; reduces the canonical phosphorylation of Smads 1,5 and 9, inhibits HeLa and MCF-7 cell proliferation; significantly reduces the tumor growth in human lung cancer xenograft model.
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In Vitro——
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In Vivo——
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SynonymsDMH1 | DMH 1
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PathwayTGF-beta/Smad
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TargetTGFBR
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RecptorALK2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1206711-16-1
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Formula Weight380.4418
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Molecular FormulaC24H20N4O
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Purity>98% (HPLC)
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SolubilityDMSO: 11.5 mg/mL
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SMILESCC(OC1=CC=C(C2=CN3C(N=C2)=C(C4=CC=NC5=CC=CC=C45)C=N3)C=C1)C
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Chemical NameQuinoline, 4-[6-[4-(1-methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hao J, et al. ACS Chem Biol. 2010 Feb 19;5(2):245-53.
2. Cross EE, et al. ACS Chem Biol. 2011 Sep 16;6(9):952-61.
3. Hao J, et al. PLoS One. 2014 Mar 6;9(6):e90748.
4. Engers DW, et al. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52.
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