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Home - Products - Wnt/Notch/Hedgehog - Wnt/beta/catenin - DK419

DK419

CAS No. 2102672-22-8

DK419( —— )

Catalog No. M26671 CAS No. 2102672-22-8

DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    DK419
  • Note
    Research use only, not for human use.
  • Brief Description
    DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM.
  • Description
    DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM. DK419 decreases protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin.It also induces production of pAMPK.(In Vitro):DK419 inhibited the growth of CRC tumor cells in vitro and had good plasma exposure when dosed orally.(In Vivo):DK419 inhibited the growth of patient derived CRC240 tumor explants in mice dosed orally.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Wnt/Notch/Hedgehog
  • Target
    Wnt/beta/catenin
  • Recptor
    LDL| UGT1A1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2102672-22-8
  • Formula Weight
    407.7
  • Molecular Formula
    C16H8ClF6N3O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 83.33 mg/mL (204.39 mM)
  • SMILES
    FC(F)(F)c1nc2cc(Cl)cc(C(=O)Nc3ccc(cc3)C(F)(F)F)c2[nH]1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ngoc TM, et al. Antioxidative activities of galloyl glucopyranosides from the stem-bark of Juglans mandshurica. Biosci Biotechnol Biochem. 2008 Aug;72(8):2158-63.
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