DEPC( —— )

Catalog No. M35853 CAS No. 1609-47-8

DEPC (Diethyl pyrocarbonate) is a potent and irreversible RNase inhibitor containing histidine residues.DEPC can be used to prevent RNA enzyme degradation by modifying histidine residues with carboxylation resulting in enzyme inactivation.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

DEPC
Note

Research use only, not for human use.
Brief Description

DEPC (Diethyl pyrocarbonate) is a potent and irreversible RNase inhibitor containing histidine residues.DEPC can be used to prevent RNA enzyme degradation by modifying histidine residues with carboxylation resulting in enzyme inactivation.
Description

Diethyl pyrocarbonate is a potent, non-specific chemical inhibitor of RNase. Diethyl pyrocarbonate has been useful in vitro as an agent relatively specific for binding to imidazole of histidine. Diethyl pyrocarbonate inhibits central chemosensitivity in rabbits. Diethyl pyrocarbonate can modify Ser, Thr, His and Tyr residues.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

Chemical Information

CAS Number

1609-47-8
Formula Weight

162.14
Molecular Formula

C6H10O5
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (616.75 mM; Ultrasonic )H2O : ≥ 33.33 mg/mL (205.56 mM)
SMILES

CCOC(=O)OC(=O)OCC
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. E E Nattie. Diethyl pyrocarbonate (an imidazole binding substance) inhibits rostral VLM CO2 sensitivity. J Appl Physiol (1985). 1986 Sep;61(3):843-50.?

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