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D715-2441
CAS No. 54245-10-2
D715-2441( D 715-2441 )
Catalog No. M14943 CAS No. 54245-10-2
D715-2441 (D 715-2441) is a novel antiviral compound that interferes with the conserved cap-binding domain of the PB2 protein.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameD715-2441
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NoteResearch use only, not for human use.
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Brief DescriptionD715-2441 (D 715-2441) is a novel antiviral compound that interferes with the conserved cap-binding domain of the PB2 protein.
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DescriptionD715-2441 (D 715-2441) is a novel antiviral compound that interferes with the conserved cap-binding domain of the PB2 protein, exhibits potent antiviral activity against influenza A viruses (IAVs) with IC50 of 1.7-4.4 uM; does not inhibit both viral entry and release, disrupts early influenza A virus replication, reduces vRNP activity and affects PB2 protein localization; shows binding affinity to influenza PB2cap protein with Kd of 0.118 uM; demonstrates a remarkable synergistic antiviral effect (FICI value of 0.40) combined with zanamivir.
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In Vitro——
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In Vivo——
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SynonymsD 715-2441
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PathwayMicrobiology/Virology
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TargetInfluenza Virus
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RecptorInfluenza Virus
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Research Area——
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Indication——
Chemical Information
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CAS Number54245-10-2
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Formula Weight228.203
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Molecular FormulaC13H8O4
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Purity>98% (HPLC)
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Solubility——
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SMILESC1=CC=C2C(=C1)C3=C(C=C(C=C3OC2=O)O)O
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Chemical Name1,3-dihydroxy-6H-benzo[c]chromen-6-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Liu T, et al. Mol Pharm. 2018 Aug 23. doi: 10.1021/acs.molpharmaceut.8b00531.
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