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Cyclapolin 9

CAS No. 40533-25-3

Cyclapolin 9( —— )

Catalog No. M33843 CAS No. 40533-25-3

Cyclapolin 9 is a selective, potent, and ATP-competitive inhibitor of polo-like kinase 1 (PLK1) with an IC50 of 500 nM, and has not shown activity against other kinases.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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10MG	337	Get Quote
25MG	523	Get Quote
50MG	723	Get Quote
100MG	963	Get Quote
500MG	1935	Get Quote
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Biological Information

Product Name

Cyclapolin 9
Note

Research use only, not for human use.
Brief Description

Cyclapolin 9 is a selective, potent, and ATP-competitive inhibitor of polo-like kinase 1 (PLK1) with an IC50 of 500 nM, and has not shown activity against other kinases.
Description

Cyclapolin 9 is a potent, selective and ATP-competitive polo-like kinase 1 (PLK1) inhibitor with an IC50 of 500 nM. Cyclapolin 9 is inactive against other kinases.
In Vitro

Cyclapolin 9 (3 μM) reduces electric field stimulation (EFS)-induced contractions of prostate strips. The α1-adrenergic smooth muscle contraction in the human prostate can be inhibited by Cyclapolin 9.
In Vivo

——
Synonyms

——
Pathway

Cell Cycle/DNA Damage
Target

PLK
Recptor

PLK
Research Area

——
Indication

——

Chemical Information

CAS Number

40533-25-3
Formula Weight

307.21
Molecular Formula

C9H4F3N3O4S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 20 mg/mL (65.10 mM; Ultrasonic (<80°C)
SMILES

NC(=O)c1sc2c(cc(cc2[n+]1[O-])C(F)(F)F)[N+]([O-])=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Martin Hennenberg, et al. Inhibition of Prostate Smooth Muscle Contraction by Inhibitors of Polo-Like Kinases. Front Physiol. 2018 Jun 15;9:734.?

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