Cornuside( —— )

Catalog No. M17939 CAS No. 131189-57-6

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Product Name

Cornuside
Note

Research use only, not for human use.
Brief Description

Cornuside has immunomodulatory activity.Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells.
Description

Cornuside has immunomodulatory activity . Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. Cornuside can treat myocardial I/R and protect the liver from CCl4-induced acute hepatotoxicity, by reducing oxidative stress and suppressing inflammatory responses. Cornuside has anti-inflammatory activity by downregulations of iNOS and COX-2 due to NF-κB inhibition as well as the negative regulation of ERK1/2, p38, and JNK1/2 phosphorylations in RAW 264.7 cells. Cornuside has protective potential against cerebral ischemic injury, may be due to the suppression of intracellular Ca(2+) elevation and caspase-3 activity, and improvements in mitochondrial energy metabolism and antioxidant properties.
In Vitro

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In Vivo

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Synonyms

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Pathway

Endocrinology/Hormones
Target

AChR
Recptor

JNK1/2|ERK1/2
Research Area

Inflammation/Immunology
Indication

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CAS Number

131189-57-6
Formula Weight

542.49
Molecular Formula

C24H30O14
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (184.34 mM)
SMILES

COC(=O)C1=COC(C(C1CCOC(=O)C2=CC(=C(C(=C2)O)O)O)C=C)OC3C(C(C(C(O3)CO)O)O)O
Chemical Name

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