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Conatumumab

CAS No. 896731-82-1

Conatumumab( —— )

Catalog No. M36720 CAS No. 896731-82-1

Conatumumab (AMG 655) is a monoclonal agonist antibody targeting human death receptor 5 [DR5, TRAILR2] with a dissociation constant (Kd) of 1 nM for long DR5 and 0.8 nM for short DR5.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Conatumumab
  • Note
    Research use only, not for human use.
  • Brief Description
    Conatumumab (AMG 655) is a monoclonal agonist antibody targeting human death receptor 5 [DR5, TRAILR2] with a dissociation constant (Kd) of 1 nM for long DR5 and 0.8 nM for short DR5.
  • Description
    Conatumumab (AMG 655) is a human monoclonal agonist antibody against human death receptor 5 (DR5, TRAILR2)(Kd: 1 nM for the long form of DR5, 0.8 nM for the short form of DR5). Conatumumab induces apoptosis via caspase activation. Conatumumab can be used in the research of cancers. .
  • In Vitro
    Cell Viability Assay Cell Line:Colo205, H-2122, and MiaPaCa2 cells Concentration:0-10 μg/mL Incubation Time:24 h Result:Dose-dependently inhibited cell viability.
  • In Vivo
    Animal Model:Mice bearing Colo205, H2122, or MiaPaCa2/T2 xenograft tumors Dosage:0, 0.1, 0.3, 1, 3, 10, 30, 100 μg Administration:Intraperitoneal injection (i.p.), twice weekly.Result:Dose-dependently inhibited tumor growth.Induced caspase-3 activation in tumors (determined by IHC).
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    TNF
  • Recptor
    TNF
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    896731-82-1
  • Formula Weight
    145.65 (kDa)
  • Molecular Formula
    ——
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Herbst RS, et al. A first-in-human study of conatumumab in adult patients with advanced solid tumors. Clin Cancer Res. 2010 Dec 1;16(23):5883-91. ?
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