Cinoxacin

Research use only, not for human use.

Cinoxacin was an older synthetic antimicrobial related to the quinolone class of antibiotics with activity similar to oxolinic acid and nalidixic acid.

Cinoxacin was an older synthetic antimicrobial related to the quinolone class of antibiotics with activity similar to oxolinic acid and nalidixic acid. (In Vitro):Cinoxacin (0-200μg/mL approximately, 3-24 h) inhibits many gram-negative aerobic bacteria with MIC values ranging from 4 to 64 μg/mL.(In Vivo):Cinoxacin (Oral administration, 1.7 g/kg, treated at 1 and 5 h postinfection) is effective in experimental bacterial infections in mice, with ED50 values ranging from 8.1 to 58.6 mg/kg.

Cinoxacin (0-200μg/mL approximately, 3-24 h) inhibits many gram-negative aerobic bacteria with MIC values ranging from 4 to 64 μg/mL. Cell Proliferation AssayCell Line:Gram-negative aerobic bacteria (Escherichia coli, Proteus sp.etc.)Concentration:0-200μg/mL approximatelyIncubation Time:3-24 hResult:Inhibited basal cell proliferation (40% in FB-2 and 35% in WRO) at 10 μM, inhibited cell number (by 68% to 73%) at 40 and 60 μM).

Cinoxacin (Oral administration, 1.7 g/kg, treated at 1 and 5 h postinfection) is effective in experimental bacterial infections in mice, with ED50 values ranging from 8.1 to 58.6 mg/kg. Animal Model:Indicated bacterial infected mice model Dosage:1.7 g/kg, treated at 1 and 5 h postinfection Administration:Oral administration Result:Displayed antibacterial activity with ED50 values ranging from 8.1 to 58.6 mg/kg.

Cinoxacine | Cinoxacino | Cinoxacinum | Acid, Azolinic | Azolinic Acid

Cell Cycle/DNA Damage

Topoisomerase

Topo II

Infection

——

28657-80-9

262.22

C12H10N2O5

>98% (HPLC)

DMSO: 10 mM

CCN1C2=CC3=C(C=C2C(=O)C(=N1)C(=O)O)OCO3

1-Ethyl-1,4-dihydro-4-oxo[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid

(-20℃)

With Ice Pack

≥ 2 years