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Home - Products - Microbiology/Virology - HCV - Ciluprevir

Ciluprevir

CAS No. 300832-84-2

Ciluprevir( BILN2061 | BILN 2061 )

Catalog No. M13936 CAS No. 300832-84-2

Ciluprevir (BILN2061) is a potent HCV NS3/4A protease inhibitor with Ki of 0.66 and 0.30 nM for NS3-NS4A protease of HCV 1b and HCV 1a, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Ciluprevir
  • Note
    Research use only, not for human use.
  • Brief Description
    Ciluprevir (BILN2061) is a potent HCV NS3/4A protease inhibitor with Ki of 0.66 and 0.30 nM for NS3-NS4A protease of HCV 1b and HCV 1a, respectively.
  • Description
    Ciluprevir (BILN2061) is a potent HCV NS3/4A protease inhibitor with Ki of 0.66 and 0.30 nM for NS3-NS4A protease of HCV 1b and HCV 1a, respectively; inhibits the replication of HCV replicon 1b and 1a with IC50 of 3 nM and 4 nM, respectively.HCV Infection Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    BILN2061 | BILN 2061
  • Pathway
    Microbiology/Virology
  • Target
    HCV
  • Recptor
    HCV
  • Research Area
    Infection
  • Indication
    HCV Infection

Chemical Information

  • CAS Number
    300832-84-2
  • Formula Weight
    774.934
  • Molecular Formula
    C40H50N6O8S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C([C@]([C@]1([H])/C=C\CCCCC[C@@H]2NC(OC3CCCC3)=O)(C1)NC([C@@](C[C@@H](OC4=CC(C5=CSC(NC(C)C)=N5)=NC6=CC(OC)=CC=C46)C7)([H])N7C2=O)=O)O
  • Chemical Name
    (2R,6S,13aS,14aR,16aS,Z)-6-(((cyclopentyloxy)carbonyl)amino)-2-((2-(2-(isopropylamino)thiazol-4-yl)-7-methoxyquinolin-4-yl)oxy)-5,16-dioxo-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-car

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lamarre D, et al. Nature. 2003 Nov 13;426(6963):186-9. 2. Lin C, et al. J Biol Chem. 2004 Apr 23;279(17):17508-14. 3. Llinàs-Brunet M, et al. J Med Chem. 2004 Mar 25;47(7):1605-8. 4. Thibeault D, et al. J Virol. 2004 Jul;78(14):7352-9.
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