Chromenone 1( —— )

Catalog No. M35539 CAS No. 1639929-29-5

Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
2MG	178	Get Quote
5MG	255	Get Quote
10MG	374	Get Quote
25MG	545	Get Quote
50MG	762	Get Quote
100MG	1017	Get Quote
500MG	2034	Get Quote
1G	Get Quote	Get Quote

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Biological Information

Product Name

Chromenone 1
Note

Research use only, not for human use.
Brief Description

Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP).
Description

Chromenone 1 is a potent osteogenic bone morphogenetic protein (BMP) potentiator. Chromenone 1 exhibits a unique mode of action as it induces a pronounced, kinase-independent, negative TGFβ feedback that enhances nuclear BMP-Smad signaling outputs.
In Vitro

Chromenone 1 rescues DMH-1-induced cardiogenesis (IC50=0.2 μM) and efficiently stimulates BMP-dependent osteogenesis from C2C12 myoblasts.
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

TGF-beta/Smad
Research Area

——
Indication

——

Chemical Information

CAS Number

1639929-29-5
Formula Weight

357.29
Molecular Formula

C18H10F3N3O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (279.88 mM; Ultrasonic )
SMILES

O=C1C(=C(OC=2C1=CC=CC2)N3C=NC=N3)C4=CC=C(C(F)(F)F)C=C4
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Wesseler F, et al. Probing Embryonic Development Enables the Discovery of Unique Small-Molecule Bone Morphogenetic Protein Potentiators. J Med Chem. 2022;65(5):3978-3990. ?

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