Chlorantraniliprole( —— )

Catalog No. M35335 CAS No. 500008-45-7

Chlorantraniliprole (Rynaxypyr) is an insecticide. Chlorantraniliprole potently and selectively activates insect ryanodine receptor.

Purity : >98% (HPLC)

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Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Chlorantraniliprole
Note

Research use only, not for human use.
Brief Description

Chlorantraniliprole (Rynaxypyr) is an insecticide. Chlorantraniliprole potently and selectively activates insect ryanodine receptor.
Description

Chlorantraniliprole is an insecticide that potently and selectively activates insect ryanodine receptor, with EC50s of 40 nM and 50 nM for Drosophila melanogaster and H. virescens ryanodine receptor, and ～300-fold more potent than that in the mouse myoblast cell line, C2C12 (EC50, 14 μM).
In Vitro

Chlorantraniliprole is an insecticide that potently and selectively activates insect ryanodine receptor. Chlorantraniliprole actions by release of intracellular Ca2+ stores mediated by the ryanodine receptor. Chlorantraniliprole is ～300-fold less potent against ryanodine receptor (RyRs) in the mouse myoblast cell line, C2C12 (EC50, 14 μM), than in insect RyRs from Drosophila melanogaster and H. virescens (EC50, 40 nM, 50 nM), and shows little selectivity at the rat cell line RyR2 (EC50, >100 μM).
In Vivo

Chlorantraniliprole has low acute mammalian toxicity with an acute oral LD50 of >5000 mg/kg in rats, and little to no toxicity in 90-day studies, at dosing as high as 1500 mg/kg/day.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

Chemical Information

CAS Number

500008-45-7
Formula Weight

483.15
Molecular Formula

C18H14BrCl2N5O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : ≥ 62.5 mg/mL (129.36 mM)
SMILES

CNC(=O)c1cc(Cl)cc(C)c1NC(=O)c1cc(Br)nn1-c1ncccc1Cl
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. George P.Lahm, et al. Rynaxypyr: A new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator. Bioorganic & Medicinal Chemistry Letters. 2007 Nov 15;17(22):6274-6279.

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